Research

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Xanthines such as caffeine and theobromine are among the most consumed psychoactive stimulants in the world, either as natural components of coffee, tea and chocolate, or as food additives. The present study assessed if xanthines affect liver sinusoidal endothelial cells (LSEC). Cultured primary rat LSEC were challenged with xanthines at concentrations typically obtained from normal consumption of xanthine-containing beverages, food or medicines; and at higher concentrations below the in vitro toxic limit. The fenestrated morphology of LSEC were examined with scanning electron and structured illumination microscopy. All xanthine challenges had no toxic effects on LSEC ultrastructure as judged by LSEC fenestration morphology, or function as determined by endocytosis studies. All xanthines in high concentrations (150 μg/mL) increased fenestration frequency but at physiologically relevant concentrations, only theobromine (8 μg/mL) showed an effect. LSEC porosity was influenced only by high caffeine doses which also shifted the fenestration distribution towards smaller pores. Moreover, a dose-dependent increase in fenestration number was observed after caffeine treatment. If these compounds induce similar changes in vivo , age-related reduction of LSEC porosity can be reversed by oral treatment with theobromine or with other xanthines using targeted delivery. ### Competing Interest Statement The authors have declared no competing interest.

Clinical studies have suggested that both MDR1 and MRP may play a significant role in the chemosensitivity and outcome of neuroblastoma. To clarify the nature of multidrug resistance (MDR) in this tumour a series of six neuroblastoma cell lines have ...

This video was created in OBS in order to comment openly on the internet-based terminology relating to "involuntary celibacy."

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New Single By Ascender:Ascender is a solo project based out of New Jersey, currently looking to branch out and form a band to release a second album and begi...

Der Kathstrauch, auch Abessinischer Tee genannt, ist eine Pflanzenart aus der Familie der Spindelbaumgewächse. Es ist die einzige Art der Gattung Catha. Die Pflanze dient der Herstellung einer berauschenden Droge und wird hauptsächlich in Jemen, Äthiopien, Somalia, Kenia und Oman angebaut.

Chinese startup DeepSeek’s new open-source model AI has sent shockwaves across the globe with President Trump calling the release a “wake-up call” for US firms

We know mobile devices can be distracting, but are they really getting in the way of a good night's rest? This study reveals how devices can interrupt sleep habits, along with other insights into how mobile devices affect family life.

Archived web material for CDC.gov is preserved on the CDC Archive Site

The Master Trust Bank of Japan, Ltd. ist eine japanische Trust- und Investmentbank. Sie arbeitet auch im Bereich der Holdings von Lebensversicherungs-Fonds. Die Gesamtsumme des in Trusts verwalteten Vermögens belief sich zum Ende des Geschäftsjahres 2007 auf 137 Billionen Yen.

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Welcome to Gard, a leading provider of marine insurance and risk management solutions, offering expert insights and coverage for the maritime industry.

In this video, we take an in-depth look at the astrological, spiritual, and energetic effects of the “May Final Portal” that opened on May 30-31. We explain ...