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Mutation of PTEN-induced kinase 1 (PINK1), which encodes a putative mitochondrial serine/threonine kinase, leads to PARK6, an autosomal recessive form…

Polyclonal Antibody for studying PINK1 (Ser228) phosphate. Validated for WB. Highly specific and rigorously validated in-house, Phospho-PINK1 (Ser228) Antibody (CST #46421) is ready to ship.

Parkinson's disease (PD) etiology has been attributed both to genetic and environmental factors, although the exact mechanisms of its pathogenesis rem…

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Shim, Studer, and colleagues demonstrate that using a floor-plate-based differentiation strategy, Parkinson's disease (PD) patient iPSC-derived mDA neurons recapitulate several PD phenotypes, including pathogenic protein accumulation, cell-type-specific vulnerability, mitochondrial dysfunction, and abnormal neurotransmitter homeostasis. The authors further propose that these phenotypes form a pathogenic loop contributing to disease.

PINK1 Antibody (C-3): sc-518052

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Hsp90-Cdc37-PINK1 complex

Understanding the function of genes mutated in hereditary forms of Parkinson’s disease yields insight into disease etiology and reveals new pathways i…

Cited in 510 publications. PINK1 antibody for WB, IHC, IF-P, ELISA and reacts with human, mouse, rat.

The gene PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] encodes a serine/threonine kinase which was initially linked to the pathogenesis of a familial form of Parkinson's d...

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